Endocrine Abstracts

Although diabetic ketoacidosis (DKA) is recognized one of complications of acromegaly, it is very rare as only five cases are reported as a primary manifestation.A 43-year-old Japanese woman, who had never pointed out impaired glucose tolerance, had emergency admitted by DKA. Her plasma glucose was 440 mg/dl, HbA1c 15.7%, urinary keton body (3+), BGA pH7.257, then she was cured by rehydration of saline and continues intravenous insulin injection. She was...

Introduction: It is known that many patients with adrenal incidentaloma display altered glucose tolerance. However, to our knowledge, we have no reports of the frequency of adrenal tumor in Japanese type 2 diabetic patients. We investigated the frequency of adrenal tumor in these patients.Subjects: We evaluated the presence of adrenal tumor in 245 Japanese type 2 diabetic patients (mean age 60.8±13.4 years). The patients who were diagnosed malignant...

Introduction: Thyroglobulin (Tg) is stored in the follicular lumen of the thyroid and serves as a substrate of thyroid hormone biosynthesis. However, it was shown that Tg significantly induces thyrocyte cell growth and suppresses expression of thyroid-functional genes. Despite having such functions, molecular mechanisms of Tg action are largely unclear. We have recently demonstrated that TSH-induced thyroid cell growth is partly mediated by a downregulation of microRNAs (miRNA...

Objective: The prevalence of primary aldosteronism (PA) occures in approximately 5–10% of patients with hypertension. Aldosterone induces fluid retention and a variety of angiopathy. We investigated the course of hypertension and renal function in the post-treatment period.Methods: Nine patients with PA were performed adrenalectomy and 21 patients were administered medications including mineralocorticoid receptor brocker. Blood pressure, serum potas...

A 31-years-old female was admitted to our hospital because of prolonged fever of unknown origin for 2 months. As she was originally diagnosed to have upper respiratory infection, antibiotics and antipyretic analgesics were prescribed. However, there is a recurrence of fever up to 39 °C without antipyretic analgesics. There were no changes in body weight or the size of clothes, and she did not notice any clinical features of Cushing’s syndrome. Her height and weight w...

Objective: This study was designed to determine whether TRAb levels are correlated with the activity and severity of Graves’ ophthalmopathy (GO).Subjects and Methods: The subjects were 179 untreated Graves’ disease patients. TRAb was assayed with Elecsys TRAb at the initial visit, and an ophthalmic assessment was performed within 3 months. The activity of the ophthalmopathy was assessed by clinical activity scores (CASs) and MRI T2 relaxation t...

Context: Postpartum hyperthyroidism (PH) is one of the postpartum thyroid disorders that occurs during the first year postpartum and PH is caused by destructive thyroiditis and recurrent Graves’ disease. PH is an exacerbation of an underlying autoimmune thyroiditis that is aggravated by the immunological rebound that follows the partial immunosuppression that occurs during pregnancy. The prevalence of PH among women with Graves’ disease (GD) who had been treated with...

Introduction: The frequency of toxic multinoduler goiter (TMNG) is different among the countries depending on an intake of iodine, but it is said to be ~1% of adenomatous goiter in Japan. In addition, the frequency of TSH-secreting pituitary adenoma (TSHoma) is rare with 0.5–1.0% of pituitary gland tumor. There is no report that TMNG coexists in TSHoma so far.Case: A 58 years old female was complained swelling of thyroid and palpitation. We found se...

Background: Graves’ hyperthyroidism is known to improve spontaneously during pregnancy due to immune tolerance, although postpartum worsening or relapse of hyperthyroidism is likely to occur.Objective: To investigate the prevalence of postpartum worsening of Graves’ orbitopathy (GO) in relation to thyroid dysfunction.Methods: This was a retrospective cross-sectional study that included 8594 patients with Graves’ dise...

Objective: Appropriate administration of anti-inflammatory and immunosuppressive treatment (AIIST) is still important for patients with Graves’ orbitopathy (GO). This study aimed to clarify the incidence of and risk factors for GO treated with AIIST, among newly diagnosed Graves’ disease (GD) patients in Japan.Methods: A total of 1558 GD patients who were newly diagnosed at Ito Hospital during the year 2011 were investigated. AIIST included loc...